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VEGF-C and VEGF-D identified as biomarkers for Avastin resistance in colorectal cancer patients

- Data presented at American Society for Clinical Oncology (“ASCO”) Annual meeting in Chicago
- Data obtained from 42 patients treated with chemotherapy (5-flourouracil and irinotecan) plus bevacizumab (Avastin®) enrolled in a Phase 2 clinical trial
- VEGF-C shown to be significantly raised just prior to and at the time of disease progression treatment resistance), while VEGF-D shown to be significantly increased after disease progression.
- Data supports concept of targeting additional VEGF family proteins to improve treatment outcomes

Melbourne, Australia June 7, 2011– Circadian Technologies Limited (ASX: CIR) announced today the presentation of data at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago USA associating resistance to Avastin® with increases in plasma VEGF-C and D concentrations.


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