Nyrada Inc (ASX: NYR) is pleased to report encouraging preclinical results from its cholesterol-lowering program to develop a drug to treat hypercholesterolemia.
A study using healthy donor human white blood cells (lymphocytes) treated with Nyrada’s PCSK9 inhibitor NYX-PCSK9i showed an increase in LDL receptor (LDLR) levels and demonstrated equivalency to marketed monoclonal PCSK9 antibody drugs evolocumab (Repatha®, Amgen) and alirocumab (Praluent®, Sanofi/Regeneron). Importantly, the results were confirmed both with and without the addition of a statin (Mevastatin), indicating the potential to develop a combined PCSK9-statin singlepill treatment for high LDL cholesterol.
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