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Immutep Announces First Patient Dosed in TACTI-002 Phase II Trial

• The First Patient has been dosed at “START Madrid- FJD” in Spain

• Clinical trial sites are active and more will be activated and commence recruitment in coming months

SYDNEY, AUSTRALIA – March 6, 2019 – Immutep Limited (ASX:IMM; NASDAQ:IMMP) ("Immutep” or “the Company”), announces the first patient has been dosed with the combination of Keytruda® and efti for TACTI-002, a Phase II clinical study.

TACTI-002 (Two ACTive Immunotherapies) is being conducted in collaboration with Merck & Co., Inc., Kenilworth, NJ, USA (known as “MSD” outside the United States and Canada). The study will evaluate the combination of Immutep’s lead product candidate eftilagimod alpha (“efti” or “IMP321”) with MSD’s KEYTRUDA® (or pembrolizumab, a PD-1 blocking antibody) in up to 109 patients with second line head and neck squamous cell carcinoma or non-small cell lung cancer in first and second line. The study will take place in up to 13 study centres across the U.S., Europe and Australia.

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