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Chimeric Therapeutics - CLTX CAR T data shows regional control of tumour recurrence


• CLTX CAR T clinical data highlighted in Keynote presentation on November 20th
• 75% disease control rate seen at lowest dose level with up to 8 weeks of durability
• Tumour recurrence prevented at sites where CLTX CAR T cells were infused while tumour recurrence occurred at sites without CLTX CAR T cell infusion
• CLTX CAR T was generally well tolerated with no dose limiting toxicities and no observed cytokine release syndrome (CRS)
• MMP2 expression confirmed as central to CLTX CAR T tumour recognition and killing
• Positive preclinical evaluation of melanoma advances CLTX CAR T towards next phase 1 clinical trial
• Webinar to be held at 11:30am AEDT today to discuss further. Click here to register.

Chimeric Therapeutics (ASX:CHM, “Chimeric”), a clinical-stage cell therapy company and the ASX leader in cell therapy, is pleased to highlight key additional data released with the final presentation of two CLTX CAR T abstracts at the Society for Neuro-Oncology (SNO) 26th annual scientific meeting.

Abstract CTIM-29, “Clinical evaluation of chlorotoxin-directed CAR T cells for patients with recurrent glioblastoma” provides insight into the initial clinical data for CLTX while abstract EXTH-10, “Exploration of a novel toxin-incorporating CAR T cell: how does chlorotoxin recognize glioblastoma cells?” expands on the translational understanding of Chlorotoxin (CLTX) activity.

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