Typically I only look at larger cap stocks but every now and again, something catches my eye and although this is a small cap stock and therefore very risky, the potential upside has definite appeal.  I don’t mind taking a risk every now and again, as long as the reward is worth the risk.
When looking at the Liver and Pancreatic Cancer treatment market, there are some very prominent companies.
Sirtex Medical  (ASX: SRX )      $37.79
Market Cap:  $2.16 billion
Biotech and Medical device group who manufacture and distribute a liver cancer treatment.
In August, Sirtex announced full year sales of 10,252 dosages (up 20%) in the last financial year at approx $18,000 a dosage.  It had revenues of $176.1 million for the year. (up 36%)
It has generally traded on approximately 10 times revenue. Ie.  It had a market cap of just over $1.8 billion after that result.
SRX announced last week that it did its first 1000 dosage month.  (Liver Cancer treatment)
 
Celgene Corp   (Nasdaq: CELG)  $122.71
Market Cap:  $98.76 Billion
Biotech company that manufactures a number of drug therapies for cancer and inflammatory disorders.
Owns Abraxane - $850 million in revenue in 2014 after FDA approval in late 2013
Forecast to do $1.5-2.0 Billion in revenue in 2017 (over 60% for Pancreatic)
One of many treatments that it owns.
 Gemcitabine – is the current standard treatment for Pancreatic Cancer (peaked at $1.7 billion in sales in 2008)
 It’s worth noting how substantial the revenues are for companies with a validated Liver or Pancreatic Cancer treatment. 
 
Oncosil Medical            (ASX:OSL)         $0.175
Market Cap :  $62 million
 Oncosil Medical (ASX: OSL) is an Australian based company with an implantable device that emits radiation into a targeted tumor.  Its limited trials (4) have had good results so far, with over 50% of the trialists experiencing a reduction in the size of their tumors greater than 30%.  Due to the lack of good treatments and poor survival rates of patients with Liver or Pancreatic Cancer, there is a large demand for new therapies to treat these cancer types.
It recently achieved its certification process and has just completed its fast tracked CE mark review process, which was conducted over 4 days in early October.  It is awaiting the results of this review and is confident that they will receive their CE mark. Due in November or anytime soon. (Pancreatic and Liver Cancer)
A CE mark will mean commercialisation of its product.  It can then start selling its treatment in some large markets in the European Union as well as Australia, Canada and Singapore.
 Recent research reports from Wilsons and from Van Leeuwenhoeck Research have indicated that this treatment has the potential to be a block buster (sales in excess of 1 billion) in the next few years.  They also expect to file for an IDE with FDA in 2016 which is likely to take approximately 18 months to two years to complete.  This will facilitate selling their treatment in the US within a couple of years.
There are a few risks here as it still has to be granted its CE mark (license to sell into EU and Australia, Canada and Singapore) but if this company is granted its license it can start selling its treatment into this very large market.
 If we make some assumptions about some future events:  I believe CE mark has an 80% likelihood of being achieved by end of 2015 and FDA is 50-60% likelihood of being achieved by end of 2017. 
 If we assume that OSL receives its CE mark in Nov 2015 and then receives its FDA approval within two years, then this company could be doing sales of greater than 10000 dosages within 3 years.
10000 dosages at $18,000 Australian = $180 million in revenue and results in a Market Cap of over $1.8 billion. This is what Sirtex Medical achieved in August 2015. With a similar pricing and margin model we can potentially value OSL if it achieves certain sales markers. 
We have presumed that OSL can start with 500 dosages in the first quarter of 2016 after achieving CE mark in mid November and then growing its market by 500 dosages every quarter following. 
Following FDA approval in Dec 2017, we would expect sales to ramp up with 1500 dosages per quarter from the US market.  FDA approval should lead to instant success and strong penetration.
Achieving 20% of pancreatic market might seem like a big ask but when you look at the current treatments – Gemcitabine (sales peaked at 1.7 billion) and Abraxane (did $850 million in revenue in 1^st year after getting FDA approval) it does put these figures into some context. 
Oncosil Medical have applied for CE mark for both Pancreatic and Liver Cancer treatments but I have just looked at Pancreatic market here alone just to give you an indication of the size of the opportunity. 
Yes there are risks with any small cap stock as things can obviously go wrong but the risk reward here is extremely appealing.
If they get their CE mark granted in next few weeks, I think they can easily go on and achieve sales of 1000 – 2000 dosages in the next 12-18 months which should give them a market cap between 180-360 million (ie $0.50 to $1.00 valuation).
In two years time if they get their FDA approval and they can grow dosages by 500 each quarter they could be doing revenues of 72 million and have a market cap of 720 million which is $2.00 a share provided no share raisings take place.
Ultimately with FDA approval and 20% of pancreatic market – it’s not unreasonable to see a $10.00-11.00 share price within 3-4 years.
From the research I have done on Pancreatic Cancer, once a treatment becomes accepted, it appears to get wide spread acceptance, with most of the market moving to use it.  Gemcitabine has shown to benefit sufferers with another 5.5 months added to survival rates and Abraxane has only benefited sufferers with another 1.5 months to their survival.  So Onconsil doesn’t have to cure cancer, it just has to show a mild improvement in survival rates.  The interesting thing with the trials so far is that there has been strong signs that radiation in the tumor, has caused a reduction in tumor size in over 80% of patients.  50% of patients have seen a reduction of over 30% in the tumor after treatment.  If only 5% of patients were able to shrink their tumors and shift their prognosis from an inoperable tumor to now being operable, then I think alot of patients would seek this treatment out as odds of survival would be greatly enhanced.
Oncologists are generally looking for a treatment that is kind to the patient and provides some relief from the pain caused by these cancers.  I believe this is a major advantage of this treatment as patients have the localised treatment, walk in and out in the same day, rather than many regular dosages of chemo.
 Most of the broker research on OSL, assumes a long term target of only 10-20% of market share.  This could be potentially underestimating the product when you look at how fast Abraxane was accepted.  It is forecast to do $1 to $1.2 billion in revenues from the pancreatic market within 3 years of being granted its FDA approval.
We bought shares at 11.5 cents on 5/5/15 for our model portfolio. We may look at adding another small parcel as this has great long term potential to bring us a large windfall.
Remember this is a high risk investment play – it is not for the conservative investor.

Don’t risk anymore than you would be comfortable enough to lose here – even though the rewards appear high.  
The company will need to achieve its CE mark soon and also get FDA approval in late 2017, so there are some big hurdles to achieve before we see more upside in the share price.  Getting its CE mark in the next month will be a big step forward in the right direction.

Primary Health care has made a bullish break out of its recent sideways consolidation.  Like alot of other stocks recently, this normally means a retest of the recent high or a marginal new high is generally what should be targeted.  NAB made a similar breakout three weeks ago and reached a new high in quick time.

In our recent stockwatch video we spoke about the importance of the 80c level on the Australian dollar and the history of support and resistance at this point.  In the last week we have seen a nice bounce off this key support zone.  A stronger Australian dollar will be positive for commodity prices and resource stocks, so this bounce could be a signifiicant factor on whethjer we see a meaningful bounce in the resource sector or not.  Some positive signs suggests at least a small to medium bounce might be possible here.  80c will remain a key price point in the future.  

Crude Oil has plummeted from $108 to $64 a barrel in a five month period.  One thing we know about vertical lows and vertical highs is that these sort of vertical markets always end with a bang.  Wide extreme ranges and a massive spike in volume almost always mark capitulation lows. 
The large volume is a sign that the sellers have basically given up in the end and the buyers finally step in after a massive decline and take a position of strength at the lows. The other ingredient is wide ranges, the high and low for the dad measure the daily range.  A capitulation will almost always end up being at the largest or very near the extreme range of this instrument. 
In Crude Oil's case, after 5 months of declining it recently had a 4% decline session, followed by a larger decline of 6% and then another 10% down the following day. The extreme moves are an indication of a capitualtion low coming. Last night it finally bounced and had a low of 63.80 and finished above 69.00 experiencing one of its largest ranges, basically a 10% range for a single session. Unless we experience a larger range in the coming days this is usually a strong sign that the low is in. This could be good news for Oil stocks trading ion the ASX like WPL, STO and OSH as recoveries can often be sharp.

Discretionary Retail stocks have been going in the opposite direction to the market in the last 12 months.  The sector has been in a large decline since November last year, so basically the stocks have pulled back 3/4 or more of the previous years range - a very large correction indeed.  Some of these stocks are starting to represent good value here and although the retail sector is experiencing tougher times, the good companies generally seem to prosper and turn positively when the cycle changes.  In particular, MYR and JBH are the two stocks that stand out currently.  The P/E is at the lower end of their trading bands and 7.5% and 5.5% yields on MYR and JBH look very enticing here.  As a contrarian investor it could be time to start looking at these two quality companies.